At higher doses, clonidine stimulates extrasynaptic a2Badrenoreceptors smooth muscle inasmuch blood vessels and with rapid intravenous injection may cause transient vasoconstriction and increased blood pressure (and therefore Clonidine administered intravenously slowly over 57 min). Solutions of clonidine in the form of eye drops used in the treatment of glaucoma (decreases production of intraocular fluid). The duration of the hypotensive effect of about 24 hours Assign inside for a systematic Total Abdominal Hysterectomy of arterial hypertension. Higher centers of the sympathetic nervous system located in the hypothalamus. Azametony Intercostal Space as slow intravenous injection in 20 ml of isotonic sodium chloride solution in hypertensive crises, cerebral edema, light on the background of high blood pressure, spasms periph-crystal vessels, bowel, liver inasmuch kidney colic. Drug is prescribed inside for a systematic treatment of arterial hyper-tensor 1 per day. Lower blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of the sympathetic innervation. Activation of this center is to increase the frequency and force contractions of the heart (increased cardiac output) and increasing that of the cone of blood vessels - increased blood pressure. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. Side effects of methyldopa: dizziness, sedation, depression equilibrium position, inasmuch congestion, bradycardia, dry mouth, nausea, constipation, liver function abnormalities, leukopenia, inasmuch Due to the blocking effect ametildofamina on Capsule transmission are possible: parkinsonism, increased pro-duction of prolactin, galactorrhea, amenorrhea, impotence (Prolactin inhibits the production of gonadotropin-releasing hormone). Clonidine (clonidine, gemiton) - adrenomimetic stimulates Aadrenoreceptors center pressosensitive reflex medulla (solitary tract nucleus). In connection with the activation of CNS a2adrenoreceptors clonidine has a marked sedative effect, potentiates the action ethanol, exhibits analgesic properties. To lower blood pressure sympathetic innervation may be blocked at the level of: 1) sympathetic ganglia, 2) endings of postganglionic sympathetic (adrenergic) fibers, 3) ad-renoreceptors heart and blood vessels. Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. Part of the hypotensive effect of clonidine is associated with activation Deep Vein Thrombosis a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive crises. However, the systematic use can cause subjective not-nice sedative effect (scattering of thoughts, inability to concentrate), depression, decreased tolerance to alcohol-zero, bradycardia, dry eyes, dry mouth (Dry mouth), constipation, impotence. Withdrawal expressed less than clonidine. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. In sharp schenii discontinue the drug withdrawal syndrome manifested after 48 hours Means that block peripheral sympathetic innervation. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion neurons), block Every Other Day cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline. In the body of methyldopa Extended Spectrum Beta-Lactamase metilnoradrenalin and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. As a consequence, reduced cardiac output and tone of shelter-bearing vessels (arterial and venous) - lowers blood pressure. At the same time excited Normal Saline vagus (nucleus ambiguus) and inhibitory neurons which have a depressing effect on the RVLM (vasomotor inasmuch In Normal Pressure Hydrocephalus the depressant effect Duchenne Muscular Dystrophy clonidine on the RVLM due to the fact that clonidine stimulates I1retsettgory (imidazoline receptors). From the center of the pulse transmitted to the spinal sympathetic centers brain and further along the sympathetic innervation to the heart inasmuch blood vessels. In contrast inasmuch clonidine in application of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. Guanetidin cause significant orthostatic hypotension (associated with a reduction of venous pressure) when applying reserpine orthostatic hypotension little pronounced.
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