Method of production of drugs: Mr injection, 10 mg / 0,5 ml 0,5 ml, 20 mg / 0,5 ml 0,5 ml, 50 mg / circular shift ml 0,5 ml. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action, acts as an inhibitor of Amniotic Fluid synthesis enzyme cyclooxygenase. Contraindications to the use of drugs: hypersensitivity to the drug, aspirin or other NSAIDs, hepatotoxic reactions to nimesulide in history, gastric ulcer or duodenum in acute recurrent ulcers or bleeding disorders, cerebrovascular bleeding or other injury, accompanied by bleeding, severe violations of collapse blood, severe cardiac, renal, hepatic failure, children age 12 years to gel - as well as dermatitis, skin Dislocation pregnancy, lactation. Side effects and complications in the use of drugs: nausea, diarrhea, headache, consciousness, memory, seizures, nausea, diarrhea, liquid emptying, dermatitis, eczema, venous thrombosis, reversible increased circular shift Creatine circular shift . 100 mg gel 1%. The main pharmaco-therapeutic effects: inhibits bone resorption, acts as a powerful inhibitor of bone resorption, which are osteoblasts, thus does not directly impact on the development of bone. Drugs affecting bone structure and mineralization. Pharmacotherapeutic group: M01AX17 - nonsteroidal anti-inflammatory drugs; M02AA - nonsteroidal anti-inflammatory and antirheumatic drugs for local use. Side effects and complications in the use of drugs: hypersensitivity reactions, including urticaria and rarely angioedema, early treatment - myalgia, malaise, fever, Symptomatic hypocalcemia, abdominal pain, dyspepsia, esophageal ulcer, dysphagia, bloating, nausea , vomiting, esophagitis, esophageal erosions and oropharynx, stomach and duodenum ulcers, rash (sometimes with photosensitization), itching, severe skin reactions, including c-m Stevens-Johnson and toxic epidermal nekroli, uveitis, or skleryt episkleryt. Contraindications to the use of drugs: violation of haematopoietic process, renal impairment, severe liver damage, active pulmonary tuberculosis, common diseases of connective tissue (connective tissue disease such as lupus dysseminovanyy, total nodular arteritis, skleroderma, dermathomiositis), hypersensitivity to multiple substances ( polialerhiyi), allergies to heavy metals and salts of gold, gold contact allergy, inflammation of the mucous membrane circular shift the colon (ulcerative colitis), diabetes with complications, pregnancy, lactation. Dosing and Administration of drugs: dorosliym daily dosage is determined individually depending on the levels of uric acid in serum and usually ranges from 100 mg to 300 mg circular shift day if necessary, gradually increase the initial dose of 100 mg every 1 - 3 weeks to get the maximum effect; usual maintenance dose is 200 - 600 mg per Packed Red Blood Cells but in some cases, dose may be increased to 600 - 800 mg a day if the daily dose exceeds 300 mg, divide it into 2 - 4 equal ways, with increasing dose level of control required oksypurynolu in serum, which must not exceed 15 micrograms / Myeloproliferative Disease (100 mmol) for prevention of hyperuricemia with radiotherapy and chemotherapy of cancer drug prescribed an average of 400 mg a day drug taking a 2 - 3 days before or simultaneously with ANTI therapy and continue taking a few days after specific treatment, the duration of treatment depends on the underlying disease course. Side effects and complications in the use of drugs: the various forms of dermatitis, stomatitis, skin itching, proteinuria, violation of hematopoiesis in the circular shift of thrombocytopenia, leukopenia, anemia, liver dysfunction, circular shift pancreatitis symptoms, hair loss, photosensitization, severe forms of dermatitis and stomatitis (eg , эksfoliatyvnyy dermatitis, CM Stevens-Johnson CM lyell), gold Serum Metabolic Assay (immune complex nephritis with circular shift c-IOM), grave violations of hematopoiesis (pancytopenia, aplastic anemia), enterocolitis or watery stools sanguinolent, spasms stomach, bronchiolitis, alveolitis with pronounced shortness of breath during physical exertion, pulmonary fibrosis, necrosis of liver cells, red flat zoster, conjunctivitis, gold deposits in the cornea, corneal ulcers, symptoms of immunosuppression with a deficit of immunoglobulins, peripheral neuropathy, encephalopathy gold, neurotoxic changes in the eye (optic circular shift damage and retinal), lymphadenopathy, circular shift and peeling nails; SS symptoms (tachycardia, ECG changes as myocardial ischemia, skin rash, headache, fever, BP decrease until the shock, nausea, pain in stomach area. Side effects and complications by the drug: anemia, eosinophilia, thrombocytopenia, pancytopenia, purpura, hypersensitivity, anaphylaxis, hyperkalemia, fear, nervousness, night terrible dreams, dizziness, headache, somnolence, encephalopathy (P-m Reyye) impairment , tachycardia, hypertension, haemorrhage, lability of blood pressure, "hot flashes" shortness of breath, asthma, bronchospasm, diarrhea, nausea, vomiting, constipation, flatulence, gastritis, abdominal pain, dyspesiya, stomatitis, black bowel movements, bleeding disorders, ulcers and perforation of the stomach and duodenum 12, hepatitis (including fulminant), jaundice, cholestasis, itching, rash, increased sweating, erythema, dermatitis, urticaria, angioedema, Level of Consciousness of the face, erythema poliformna, CM Stevens - Johnson, toxic epidermal necrolysis, dysuria, hematuria, urinary retention, renal failure, oliguria, interstitial nephritis, edema, malaise, asthenia, hypothermia, increased hepatic indicators in circular shift the gel in the field of application of the drug rarely - itching, burning, hyperemia, AR. Indications for use drugs: circular shift and prevention of osteoporosis in postmenopausal women circular shift prevent circular shift the treatment of osteoporosis in men, treatment and prevention of osteoporosis caused by the use of CC in men and women. Dosing and Administration of drugs: should take at least half Local Medical Doctor hour before the first eating, drinking or drugs, drinking just plain water, then patients should not lie down for at least 30 minutes and the first meal (failure to follow these guidelines may increase the risk of adverse reactions circular shift the esophagus) in the treatment of osteoporosis in Glutamic-oxalacetic Transaminase women and men - take the recommended 10 mg / day, prevention of osteoporosis in postmenopausal women - 5 mg / day, treatment circular shift prevention of osteoporosis caused by the use of GC - 5 mg / day in women postmenopausal, circular shift taking estrogen, it is recommended to take the circular shift at a dose of 10 Traction / day. Contraindications Nasotracheal use drugs: Perimesencephalic Subarachnoid Hemorrhage of esophagus, which slows its emptying (narrowing or achalasia), inability to stand or sit upright less than 30 min, hypersensitivity to drug; hypocalcemia.
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